Showing posts with label Stem Cells. Show all posts
Showing posts with label Stem Cells. Show all posts

Wednesday, November 12, 2008

Science may make a comeback


President-Elect Barack Obama has set science and society up for success with his new agenda:

The economy and foreign policy may be higher on President-elect Barack Obama's to-do list, but science and technology issues are on the radar screen as well. Among the top tasks: taking the ideology out of scientific issues, and doing more about what Obama has called a "planet in peril."

This is good news for many reasons, one of which: I'm tired of writing cynical blog posts relating to stem cells. Give me some better material to work with!

Tuesday, November 20, 2007

Puff Puff


More stem cell puffery:

"By avoiding techniques that destroy life, while vigorously supporting alternative approaches, President Bush is encouraging scientific advancement within ethical boundaries," the White House said Tuesday in a written statement on the new research.

By avoiding direct routes that get people to work on time, while vigorously demanding that everyone take the congested side streets, we are encouraging people to "get to work on time" --

within "certain boundaries".

Thursday, June 21, 2007

Ethical Responsible-ness-ity


Bush blows raspberries toward another stem cell research bill:

Vetoing the bill a second time Wednesday, Bush also sought to placate those who disagree with him by signing an executive order urging scientists toward what he termed "ethically responsible" research.

Bush announced no new federal dollars for stem cell research, which supporters say holds the promise of disease cures, and his order would not allow researchers to do anything they couldn't do under existing restrictions.

"If this legislation became law, it would compel American taxpayers for the first time in our history to support the deliberate destruction of human embryos," Bush said. "I made it clear to Congress and to the American people that I will not allow our nation to cross this moral line."

It is, however, "ethically responsible" to continue to fund embryonic stem cell research fueled by the blood of potential babies gathered prior a certain date:

On 9 August (2001), eager to please everybody, especially his conservative supporters, Bush tried another form of compromise, in a well-worded speech that suggested personal agony, as well as political astuteness. Bush reminded listeners, in a reference to use of fetal tissue transplants for Parkinson's disease, that promising scientific endeavors do not always succeed. He ruled that the government could fund research on stem cells that had been derived before, but not after, 9 August provided that they came from embryos left over after fertility treatments (thereby excluding the embryos created specifically for research by the Jones Institute).

The compromise was that the government should not encourage destruction of more embryos, but since the damage had already been done in the case of cells derived before 9 August, and the potential to treat disease was real, use of these cells should be funded. Bush's well-worded speech did not please everyone, though most conservatives (with the notable exception of the National Conference of Catholic Bishops) have remained quiet. Many scientific groups, including the American Society of Human Genetics, have offered cautious praise, largely because the statement sets a precedent for federal funding, which they hope may be expanded if preliminary research succeeds. Bush's statement is illogical and without a basis in principled reasoning. There is no reason, beyond the political, why it should be ethical to use stem cells from blastocysts killed before the arbitrary cut-off date of 9 August, but not afterwards.

It also must be "ethically responsible" to allow the killing fields in the private sector to continue, provided they are not funded by taxpayers:

Federal funding for research involving mouse embryonic stem cells and adult stem cells (both mouse and human) is currently available and is not restricted. However, federal funding for research involving human embryonic stem cells is limited to research involving only those cell lines that were approved by the Bush administration in August 2001. In contrast, no restrictions in the type of research that can be performed with private funds are in place.

You know, like how homicide is allowed as long as it's for-profit.

Thursday, June 07, 2007

Stem Cell Mimics, not Replacements


Scientists are having luck with manipulating mouse cells to emulate some of the qualities of embryonic stem cells (ESCs)--and CNN blows the story before the end of the first misleading sentence:

NEW YORK (AP) -- What if scientists could find a way to produce embryonic stem cells without having to tamper with embryos?

1) They aren't producing embryonic stem cells. They've successfully rewired mouse (iPS) cells to emulate ESCs in various lab tests, although there are still some key differences, such as their capacity to "promote cancer in any patients getting therapy based on [iPS cells]".

More on those differences:

In addition, scientists still must show that these cells can give rise to many cell types in the lab, as embryonic stem cells can.

And all this must be accomplished in human cells -- a difficult task, because introducing genes into human cells is a major challenge.


Ah, Science and your bite-sized breakthroughs!

2) This whole "tampering" business is a crock. We're already tampering with embryos regardless of whether we partake in ESC research, and it's not as bad as it sounds:

ESCs are taken from extra 5-day-old embryos artificially fertilized in a laboratory by the wishes of the aspiring parents. Markedly early in development, the embryo numbers about 100 cells (compare that to the 10,000,000,000,000 cells in an adult). At this stage in the natural female body this bundle of cells has not even reached the uterus, the mother’s womb, where fertilized eggs have to initially implant for a pregnancy to even begin, as is the medical consensus.

I've written about the debate before so I don't have much more to add at the moment, other than how infuriating it is to hear the deputy director of pro-life activities for the U.S. Conference of Catholic Bishops say he's "very encouraged" that we've made progress into making ESC mimics, which will take longer to produce cures and therapies for the millions of people suffering from serious medical conditions and diseases. Yeah, it's encouraging to know that scientists are gallivanting about trying to make alternatives to ESCs because of a provincial ethical outlook that currently dictates the management of federal funding. Right.

Wednesday, April 11, 2007

Stem-cell Research = Slavery


...so said one of the 34 legislators today that voted against loosening restrictions for federally funding embryonic stem-cell research:

"Its end is the way of death," said Brownback, a Republican presidential hopeful. "It kills a young human life. It harms us as a culture when we treat human life as property. We've done that. We don't like it. We don't like the history associated with it."

A few points of interest:

1) There is no real counterargument to the fact that slaves are, indeed, individual persons with their own individual self-awareness. Not so for Embryonic Stem Cells (ESCs).

2) Slavery is a root cause of the current state of institutionalized racism. Not so for ESCs.

3) Slavery is the buying and selling of human beings as property, whereas ESC research is the use of extra cells after in vitro fertilization that are destined to be destroyed anyway. There is no buying and selling--instead, ESC research is about recycling material that was already being utilized.

4) Individual versus societal impact: Slavery gave benefits to individual owners but negative consequences to society in the form of race hatred. ESC research contributes more project ideas to individual scientists and greatly to science and the health of society.

Sunday, January 07, 2007

New vote on stem cells


I'm back in Berkeley, and beginning another spring staff training, but posts should continue at a reasonable interval.

Also, just spreading the word:


More than 5 long years into President Bush's short-sighted, cruel policy restricting stem cell research, America once again has the chance to reverse it -- and strike a blow for hope.


On January 11, 2007, the House of Representatives will vote on H.R. 3, a bill to overturn President Bush's restrictions. The Senate is expected to vote shortly thereafter. Although stem cell research has bipartisan support, "pro-death" activists are working hard to torpedo this bill, and take hope away from millions of Americans. Please write your members of Congress today, and ask them to support this bill:


Because President Bush may veto it, it is critical that we not only pass it -- but that we reach the 2/3 majority necessary to override the veto. Every vote counts -- and every email from you counts. So write your members today, tell them to support H.R. 3, and tell your friends to do the same:


http://www.stempac.com


Thursday, July 27, 2006

Stem Cells: Science at the Steps of Decency


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Victims of a wealth of diseases, disorders, and crippling injuries enjoyed hope for what lasted only a short time, when on last Thursday President Bush threw down his gloves and swaggered “Bring ‘em on” to scientists and free-thinkers alike:
“I hold to the principle that we can harness the promise of technology without becoming slaves to technology and ensure that science serves the cause of humanity. If we are to find the right ways to advance ethical medical research, we must also be willing when necessary to reject the wrong ways. For that reason, I must veto this bill.”
His only veto of his entire presidential career, I guess we should have expected it would have come in the form of stalling scientific progress. Science and Ethics are always considered polar opposites when we listen to the perspectives of those on the Pro-Life side of the debate. However, this is a gross oversimplification that is simply not true: science and morality are more often interwoven than not, research scientists themselves being some of the most honest, truth-abiding people out there in our society. I pose this question: what type of person would choose a job that paid little, expected lots, and placed intense scrutiny from educated peers on his or her ongoing research constantly? There is no room for intellectual dishonesty with an occupation rooted in empirical evidence, where logic and honesty are the only realities possible.

Science and Ethics are particularly in agreement when it comes to the issue of embryonic stem cells, and to better understand this we need to deconstruct the sale of Morality by our opponents.

President Bush said in his veto photo-op:
“Yet, as science brings us ever closer to unlocking the secrets of human biology, it also offers temptations to manipulate human life and violate human dignity.”
Bush’s justification for his stance on embryonic stem cell research picks and chooses tenets of a morality that he cares to employ and to preach (protecting the sanctity of aspiring life), while skipping over others (protecting the sanctity of existing life). He packages his own version of morality and sells it to the nation as evidence for his actions, one of the reasons even his political party, and some of them Pro-Lifers, are divisive about the issue. This dissent comes from the same group of misfits that all recently agreed to embrace the Iraq War—yes, that one nation that has descended into chaos under our watch— as a key issue this fall. How could it be that a bloc of politicians can agree to run on the war amidst failing public opinion and security, with a linearly increasing civilian death toll, but not seem to get their opinions squared away with Bush’s principled delivery? It seems there are some forces at play here that rival the mystique of quantum physics.

Well, maybe not. President Bush again highlights the inherent variability of his morality by his response to stem cell research. He claims that science tempts us to “manipulate human life,” which it does. In fact, we do so on a day-to-day basis, and are lauded for our achievements. Human egg cells are routinely fertilized and destroyed in an unnatural laboratory setting, cell division and thus the growth of new and healthy cells is inhibited by chemotherapy, cadavers are donated for medical research and practice, organs donated and transplanted hither and thither, volunteers for clinical studies on drugs that need to be proven to work, and the list goes on. All of these endeavors were absolutely necessary for science and technology to have advanced as far as they have, and there’s still an infinite amount more we need to accomplish. Bush asserts that his stance on stem cell research is because it is temptation to manipulate life, an ethically-challenged position that is provincial to the myriad other ways that scientists do—and must—manipulate life to effect change, an ethical decision made by those who are passionate about engendering a more enjoyable life for society through advances in science.

While the case against abortion on the grounds of morality might be tenable through a moral principle to uphold life at any cost (no matter how insanely intrusive this compels our government to be), that same principle does not hold water with this issue, as I’ve explained before. Is it really an ethical decision to assume a 5-day-old embryo (or blastocyst), a structure comparatively not unlike that of a lone sperm or ovum, warrants the same rights and liberties as that of an independently-living human being, even when this decision trumps the rights of the suffering to potential panaceas? What’s more, opponents often cite the dreaded slippery slope of such a moral distinction between life and non-life, saying that if the “utilitarian” case for ESC research is made, what’s to stop “immoral” scientists from pushing the envelope and claiming embryos in the 1st and fetuses in the 2nd and 3rd trimester are also non-life? This is preposterous in the sense that the envelope can more easily be pushed in the opposite direction: if 100 cells constitute human life, why not 50, or 10, or even a lone sperm and egg, seeing as how they, too, have the potential to merge and implant in the uterus and lead to a pregnancy? Are we to then conclude that male masturbation and a woman’s period are also morally reprehensible?

If we extend the same morality inherent in Pro-Lifers fighting for human rights for the developing fetus to the prospect of scientific research with blastocysts, we come to the conclusion that scientists are operating with a similar morality in mind: to defend the sanctity and security of human life at all costs. We manipulate life in the way that science has always done so, with respect for our fellow man and the dignity of mankind, to aim for advancing our consciousness and understanding our purpose on this earth. In the context of ESC research, our best hypothesis is that this branch of science will offer tremendous help in understanding developmental biology and the mechanisms of cancers and genetic disorders, in testing new drugs, and even in cell-based therapies involving healthy tissue generation. It would be downright, dare I say, immoral to pick-and-choose certain aspects of morality but not others to justify stalling this research.

Alas, that is the key difference between our morality and Bush’s: we do not screen ethics for principles that best suit us and our purposes (read: riling up the rapture-ready conservative bible-thumping base for an election year), nor do we flip-flop on our commitment to sustaining and promoting the welfare of life. We unequivocally and morally advance society through intellectual stages of development as we have done since the beginning of time, desiring nothing less than continuing the pursuit of unknown knowledge, for ours and our children’s sake.

Sunday, July 23, 2006

Embryonic Stem Cells and Abortion(?)


(I wrote this as a comment on another thread but feel it adequetely gets across my point. I have another piece on this topic that I'll upload whenever I finish it.)

One of the problems we run into with this debate is conflating it and its ethical dilemmas with abortion, even though the two are not alike. Logically, one can still consider oneself Pro-Life on abortion and also support federal funding of ESC research, and I wish scientists would say it more often.

Take a look:

Fetal Development

Abortions normally take place within the 1st trimester, or first 13 weeks of a pregnancy. The embryo is developing at this stage, implanted in the uterus, growing with the help of nutrients supplied by its mother. Having an abortion is normally the mother’s choice and results in termination of the pregnancy and little other effect on society. However this influences your stance on abortion, it really has no bearing on the topic at hand.

ESCs are taken from extra 5-day-old embryos artificially fertilized in a laboratory by the wishes of the aspiring parents. Markedly early in development, the embryo numbers about 100 cells (compare that to the 10,000,000,000,000 cells in an adult). At this stage in the natural female body this bundle of cells has not even reached the uterus, the mother’s womb, where fertilized eggs have to initially implant for a pregnancy to even begin, as is the medical consensus. Thus one may argue that abortion is unethical because gestation has without a doubt occurred, but will equivocate about how a 5-day-old embryo is technically still almost a beaming baby boy, even when the medical community begs to differ. Framing the debate with this in mind would assist more Americans in keeping an open mind to the logistics and implications of ESC research.

Pro-Life or Pro-Choice, those who feel morally obligated to interfere with scientific research into ESCs because of a doctrine that life beings at the onset of fertilization should also be calling on a ban of oral contraception, but you can imagine how well this political stand would hold up. To clarify, withholding federal funds from a normally federally-funded entity that relies excessively on these funds constitutes a ban on that entity. Cut this funding out from the rest of our research programs and you'd see our pursuit of scientific and technological breakthroughs quickly come to a halt.

The fact that ESC research—or any scientific research, for that matter—needs to be funded by the government is evident by the benefits it gives to society. Scientific and technological advances provide cures for diseases, prolonged health into old age, and knowledge about the physical world around us. Everyone partakes of these benefits, making it a good reason our tax dollars should be footing the bill. Should highways, education, and domestic security also be funded by private donors?

And as already mentioned before, vetoing federal funding is pretty much the same thing as vetoing the entire project, which is a disillusioning thought. Scientists (real ones, with an honest interest in the subject rather than politics) are very enthusiastic about the possibilities with ESC, and with even a limited knowledge of what ESCs are and what they can be used for—which aside from the usual tissue repair reasoning, include giving some critical information about cell developmental biology and help with understanding the mechanisms of cancers and genetic disorders— it’s difficult to find them so morally corrupting.

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